Mixed Ligand Complexes Containing (2-Hydroxy- 4 -Methoxyphenyl) (Phenyl) Methanone and 2-Aminophenol: Synthesis and DNA Cleavage
P. Subbaraj1, A. Ramu, N. Raman2, J. Dharmaraja3
1P. Subbaraj, Assistant Professor, Department of Chemistry, Devanga Arts College, Aruppukottai – 626 101, Tamil Nadu, India.
2A. Ramu, Professor and Head, Department of Inorganic Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai – 625 021, Tamil Nadu, India.
3N. Raman, Associate Professor, Research Department of Chemistry, V.H.N.S.N. College, Virudhunagar – 626 001, Tamil Nadu, India.
4J. Dharmaraja, Assistant Professor, Department of Chemistry, Sree Sowdambika College of Engineering, Aruppukottai – 626 134, Virudhunagar District, Tamil Nadu, India.
Manuscript received on May 11, 2013. | Revised Manuscript received on May 15, 2013. | Manuscript published on May 25, 2013. | PP: 79-84 | Volume-1 Issue-7, May 2013. | Retrieval Number: G0310051713/2013©BEIESP
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© The Authors. Published By: Blue Eyes Intelligence Engineering and Sciences Publication (BEIESP). This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
Abstract: A bidentate NO type Schiff base ligand (HA) has been obtained by the condensation reaction of 2-hydroxy-4- metoxy benzophenone with aniline. Using this Schiff base as main ligand(HA) and 2-aminophenol as co-ligand (B), few novel mixed ligand complexes of composition MAB [M = Mn(II), Co(II), Ni(II), Cu(II) and Zn(II)] have been synthesized. The resulting Schiff base (HA) and the mixed ligand complexes have been structurally characterized by UV-Vis., IR, 1H-NMR, FABMass, EPR, XRD, SEM and magnetic studies. XRD and SEM reveal that all the complexes are microcrystalline nature with uniform morphology. In-vitro biological activities of free Schiff base (HA) and the mixed ligand complexes (1-5) were screened against few pathogenic bacterial and fungal strains by well diffusion technique. All the complexes show moderate potent activities than Schiff base ligand. Furthermore, the oxidative DNA cleavage activities of free Schiff base and the mixed ligand complexes have been done by agarose gel electrophoresis method in peroxide medium.
Keywords: Mixed ligand complexes, Powder XRD, SEM, Biological, DNA activity