Synthesis, Growth, Structural Elucidation and Pharmacological Activities of o–Aminobenzamide and L–Asparagine derived Ni(II), Cu(II) and Zn(II) Compounds
M. Chitra1, M. Revathi2, J. Dharmaraja3, S. Shobana4, M. Anusuya5
1M. Chitra, Research Scholar, Department of Physics, Prist University, Madurai Campus, Arasanoor Village, Sivagangai – 630 561, Sivagangai District, Tamil Nadu, India.
2M. Revathi, Assistant Professor, Department of Physics, Prist University, Madurai Campus, Arasanoor Village, Sivagangai – 630 561, Sivagangai District, Tamil Nadu, India.
3J. Dharmaraja, Associate Professor & Head, Department of Chemistry, Sree Sowdambika College of Engineering, Aruppukottai – 626 134, Virudhunagar District, Tamil Nadu, India.
4S. Shobana, Assistant Professor, Department of Chemistry and Research Centre, Aditanar College of Arts and Science, Virapandianpatnam, Tiruchendur–628 216, Thoothukudi District, Tamil Nadu, India.
5M. Anusuya, Assistant Professor, Department of Chemistry, Sree Sowdambika College of Engineering, Aruppukottai – 626 134, Virudhunagar District, Tamil Nadu, India.
Manuscript received on July 17, 2017. | Revised Manuscript Received on July 19, 2017. | Manuscript published on July 25, 2017. | PP: 18-25 | Volume-4 Issue-12, July 2017. | Retrieval Number: L12030741217/2017©BEIESP
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© The Authors. Published By: Blue Eyes Intelligence Engineering and Sciences Publication (BEIESP). This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
Abstract: The present study mainly investigates the synthesis and growth of some novel bioactive Ni(II), Cu(II) and Zn(II) compounds (1–3) derived from 2–aminobenzamide (o– aminobenzamide: 2AB: L) and L–asparagine (asn: B). The synthesised compounds were structurally characterized by various physico–chemical and spectral (FTIR, UV–vis., TGA/DTA, XRD and SEM) studies. The micro elemental (C, H and N) analysis suggests that stoichiometry of the metal(II) compounds to be 1:1:1 (Metal: 2AB: asn). The observed low molar conductance values reveal their non–electrolytic nature and the observed electronic spectra coupled with magnetic moment values clearly indicate that the ligands 2AB (L) and asn (B) coordinate with metal(II) ions in tetradentate manner through amino–N & amido–O of (L) and deprotonated carboxylato–O & amino–N atoms of (B) to form a stable 6, 5 membered chelate ring. Powder X–ray diffractogram and SEM pictograph implies that all the compounds have well–defined nanocrystallinity with homogeneous morphology. All the derived compounds (1–3) show significant in vitro biological and antioxidant activities than the 2AB(L) and asn(B) in their free state and the activities go behind the order as Control >> CuLB >> NiLB ≈ ZnLB > 2AB(L) > asn(B).
Keywords: 2–Aminobenzamide, L–Asparagine, Spectral, XRD, SEM, Pharmacological study.